Techno‐economic analysis of dynamic, end‐to‐end optimal pharmaceutical campaign manufacturing using <scp>PharmaPy</scp>
نویسندگان
چکیده
Increased interest in the pharmaceutical industry to transition from batch continuouos manufacturing motivates use of digital frameworks that allow systematic comparison candidate process configurations. This article evaluates technical and economic feasibility different end-to-end optimal configurations, namely, batch, hybrid continuous, for small-scale an active ingredient. Production campaigns were analyzed those configurations containing continuous equipment, where significant start-up effects are expected given relatively short campaign times considered. Hybrid operating mode was found be most attractive configuration at intermediate large annual production targets, which stems combining reactors semi-batch vaporization equipment. Continuous operation more costly, due long stabilization crystallization, thermodynamic limitations flash vaporization. Our work reveals benefits evaluation operate under feasible conditions compliant product quality attributes.
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15 صفحه اولPharmaceutical Manufacturing Leveraging.cdr
Ashok Khanna has over 19 years of industry experience in the field of healthcare, hi-tech and telecom. As a business leader, his expertise spans multiple medical and pharmaceutical domain areas including new product development, product lifecycle management, manufacturing operations management, R&D and quality, regulatory and product sustenance. With over 21 years of experience in the IT indust...
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ژورنال
عنوان ژورنال: Aiche Journal
سال: 2023
ISSN: ['1547-5905', '0001-1541']
DOI: https://doi.org/10.1002/aic.18142